Entrepreneurship researchers have studied resilience across various contexts, including at the micro (that is, owner/business) and macro (that is, cluster/ecosystem/region) levels, by drawing from a myriad of academic disciplines. This Special Issue (SI) provides an opportunity to link resilience at the micro- and macro-level since collective small business owner resilience is foundational to macro-level resilience within clusters, ecosystems and regions. This point has become evident as businesses worldwide face similar challenges and economic adversities due to the lockdowns during the global COVID-19 pandemic. The collection of papers on small business resilience in this SI indicates the psychological, organizational, and economic responses undertaken by small businesses to overcome challenges faced, where they promoted their human, social, and financial capital while finding other responses less helpful. We hope the research and questions uncovered as a result of this SI provide continued food for thought and grounds for future research in small business resilience.